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U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds. This compound has never received FDA approval and there are no reported human cases in the literature involving an U-50488 overdose U-50488-D 3 hydrochloride solution. 1 Product Result | Match Criteria: Product Name, Description Empirical Formula (Hill Notation): C 19 H 23 D 3 Cl 2 N 2 O · HCl. Molecular Weight: 408.81. U-008 ; 100 μg/mL in methanol (as free base), certified reference material, ampule of 1 mL. Showing 1-3 of 3 results for U-50488 Advanced Search. Structure Search. Relevance. Compare. U-50488-D 3 hydrochloride solution. U-50488-D 3 hydrochloride solution. Molecular Weight: 408.81. Empirical Formula (Hill Notation): C 19 H 23 D 3 Cl 2 N 2 O · HCl. Product Number Product Description SDS; U-008: 100 μg/mL in methanol (as free base), certified reference material, ampule of 1 mL. Selective κ-opioid receptor agonist. (±)-trans-U-50488 methanesulfonate salt is known to induce diuresis. U-50488H is found to prevent morphine tolerance when administered along with it (+)-U-50488 Hydrochloride | C19H27Cl3N2O | CID 6918162 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological.

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References for (-)-U-50488 hydrochloride. References are publications that support the biological activity of the product. De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335 PMID: 2822490 . Morrone et al (1993) Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ. U 50,488H; U 50488; U 50488H; U-50,488H; U-50488H; U50,488H; U50488; U50488H: Recent clinical studies. Etiology. Analysis of fentanyl analogs and novel synthetic opioids in blood, serum/plasma, and urine in forensic casework. Moody MT, Diaz S, Shah P, Papsun D, Logan BK Drug Test Anal 2018 Sep;10(9):1358-1367. Epub 2018 May 3 doi: 10.1002/dta.2393. PMID: 29633785. Behavioral effects of a novel.

U-50488 39K8JHE8XN Overview Structure Names 4: Identifiers 4: Relationships 1: Active Moiety 1: Audit Info References 8: Moieties 1: Substance Class: Chemical Record UNII: 39K8JHE8XN. Record Status: Validated : Record Version: Show Definitional References Hide Definitional. (Preusmjereno sa U-50,488) U-50488 je lek koji deluje kao visoko selektivni agonist κ-opioidnog receptora, bez μ-opioidnih antagonističkog dejstva. On ima analgetske, diuretske i antitusivne efekte, i poništava memorijski uticaj antiholinergičkih lekova (+)-U-50488 hydrochloride is a selective KOR agonist. In isolated rat DRG neurons, U-50488 (0.3-40 μM) inhibited voltage-independent Ca2+ channel currents. In HeLa cells that didn't express KOR, U-50488 (20 μM) blocked Ca2+ channels. In rhesus monkeys, U-50488 exhibited potent antinociceptive activity and produced diuresis

u-50488 Sigma-Aldric

Buy (±)-trans-U-50488 methanesulfonate salt (CAS 83913-05-7), a selective κ-opioid receptor agonist, from Santa Cruz. MF C19H26Cl2N2O•CH4O3S, MW 465.4 References for (±)-U-50488 hydrochloride. References are publications that support the biological activity of the product. Pao-Luh Tao et al (1994) U-50,488 blocks the development of mor. tolerance and dependence at a very low dose in guinea pigs. Eur.J.Pharmacol U-50,488 showed no effect on adenylyl cyclase activity, neither in non-stimulated membranes nor in membranes stimulated by isoprenaline or forskolin. Furthermore, the effects of the specific inhibitor of phospholipase C, U-73,122 and specific inhibitor of protein kinase C, chelerythrine, on the contraction amplitude were investigated. The decrease in contraction amplitude in the presence of U.

U-50488 Sigma-Aldric

trans-U-50488 methanesulfonate salt - Sigma-Aldric

  1. (преусмерено са U-50,488) U-50488 je lek koji deluje kao visoko selektivni agonist κ-opioidnog receptora, bez μ-opioidnih antagonističkog dejstva. On ima analgetske, diuretske i antitusivne efekte, i poništava memorijski uticaj antiholinergičkih lekova
  2. Keywords: (+)-U-50488 hydrochloride, (+)-U-50488 hydrochloride supplier, selective, agonists, enantiomer, κ-opioid, kappa-opioid, KOP, Receptors, OP2, Kappa, Opioid, 0471, Tocris Bioscience. Citations for (+)-U-50488 hydrochloride. Citations are publications that use Tocris products. Currently there are no citations for (+)-U-50488 hydrochloride. Do you know of a great paper that uses (+)-U.
  3. al nucleus slices. Suarez-Roca and Maixner J.Pharmacol.Exp.Ther., 1993;264:64
  4. U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects. It has analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs. U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds
Other novel synthetic opioids: (A) AH-7921; (B) U-47700

U-50488 (hydrochloride) SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 1272/2008 1.1 Product Code: 19363 Section 1. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: U-50488 (hydrochloride) Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. Ann Arbor, MI 48108 Emergency Contact: CHEMTREC Within USA and Canada: +1. U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990. Szmuszkovicz J(1). Author information: (1)Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556-5670, USA. All clinically significant analgesics for severe pain derive from the morphine model. Morphine has provided a fertile area for medicinal chemistry research and received an.

U-50488 Hydrochloride C19H27Cl3N2O - PubChe

  1. dern oder blockieren können, während κ-Antagonisten (Norbinaltorphi
  2. U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects. It has analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs. U-50488 was one of the first selective kappa agonists invented
  3. English: Structure of U-50488. Date: 23 January 2016: Source: Own work: Author: Aethyta: Licensing. I, the copyright holder of this work, hereby publish it under the following licenses: Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no.
  4. U-50488 je lek koji deluje kao visoko selektivni agonist κ-opioidnog receptora, bez μ-opioidnih antagonističkog dejstva.[4] On ima analgetske, diuretske i antitusivne efekte,[5] i poništava memorijski uticaj antiholinergičkih lekova.[6] U-50488 je bio jedan od prvih selektivnih kapa agonista i istraživanja osobina njegovih derivata su dovela do razvoja velike familije srodnih jedinjenja.
  5. U-47700 may also be an agonist for the kappa-opioid receptor system. As a result of this, it has become the lead compound of selective kappa-opioid receptor ligands such as U-50488 and U-69,593, which share very similar structures. Its structure led to other chemists experimenting with it to see if rigid analogs would retain activity
  6. es U-50,488 agonist antagonist apomor-phine galantha

U-50488 hydrochloride Supplier CAS 114528-79-9 Tocris

U-50488 enhanced contraction of the rabbit vas deferens induced by electrically with IC50 value of 26.5 nM. In mice, U-50488 impaired motor function with ED50 value of 15.3 mg/kg and reduced spontaneous activity [3]. In adult rats, U-50488 increased the threshold required to maintain self-stimulation responding, a depressive-like effect. While, males were significantly more sensitive than. (+)-U-50488 hydrochloride(114528-81-3) Reference standards for Pharmacological research. (+)-U-50488 hydrochloride is a selective agonist for κ-opioid receptor [1]. The κ-opioid receptor (KOR) is a type of opioid r View and buy high purity (+)-U-50488 hydrochloride. Selective κ agonist; less active enantiomer of (±)-U-50488 (Cat. No. 0495)

U-50488 (Concept Id: C0147448

(+)-U-50488 hydrochloride is a selective agonist for κ-opioid receptor [1]. The κ-opioid receptor (KOR) is a type of opioid receptor for opioid peptide dynorphin and controls addiction. Also, KOR plays an important role in stress, anxiety, an

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U 50488 - chemical information, properties, structures, articles, patents and more chemical data Less active enantiomer of (±)-U-50488 . Racemate and (-)-enantiomer also available. This product(s) resides on a Fisher Scientific GSA or VA contract. If you are viewing this page as a nonregistered user, the price(s) displayed is List Price. To view your GSA or VA contract pricing, log in using your account number, or become a registered user by contacting one of our Customer Service teams. U-50488 is selective for the K opioid receptor. Its mostly used in kappa research. Kappa agonists are not fun, they cause dysphoria. It could be used as an analgesic, for someone brave enough to take an aversive substance. So TLDR only buy if you're in great pain and nothing else is working. U-47931e is a more typical mu-opioid receptor agonist. This means it should be a more enjoyable. U-50488 has been studied in animal models for its analgesic, diuretic, antitussive and anticonvulsant properties . KOR agonists also mediate the dysphoria and hallucinations associated with drugs such as levorphanol, pentazocine and salvinorin A. U-50488 is currently uncontrolled and available from online research chemical supply companies; however, its abuse potential is unknown. KOR agonists. Country/Region selector. (800) 343-7475 Contact Us Live Chat Car

U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects. It has analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs. U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related. The U-50488 concentration-response relationship and whether the receptor agonist inhibited Ca 2+ currents in a voltage-dependent or -independent manner were not determined. Therefore, it is hard to reconcile the observed differences. Finally, we observed that another κ-OR blocker (5′-GNTI) failed to inhibit the U-50488 modulatory effects at relatively high concentrations. The. 67198-13-4 - VQLPLYSROCPWFF-QZTJIDSGSA-N - U-50488 - Similar structures search, synonyms, formulas, resource links, and other chemical information

APExBIO - (+)-U-50488 hydrochlorideSelective κ-opioid

Opioid Receptor - Endocrinology and Hormones - Signaling

U-50488 [trans-3,4-dichloro-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide] is a structurally novel analgesic reported to have specific kappa opioid receptor agonist properties. Potent antinociceptive activity was demonstrated in rhesus monkeys and the effect was reversed by naloxone. The overt behavioral effects of U-50488 at supra-analgesic doses more closely resembled those of. To establish (±)-U-50488 as a discriminative stimulus, rats (n = 12) were trained to discriminate intraperitoneal (i.p.) administration of 5.6 mg/kg of (±)-trans-U-50488 from saline under a fixed-ratio 20 (FR-20) schedule of food reinforcement. Then, antinociception was assessed using two procedures: warm water tail withdrawal and von Frey paw withdrawal. Diuretic effects were assessed in. U-50488 is an opioid receptor agonist that was originally developed by the Upjohn Company in the 1970s as a κ-selective derivative of U-47700 . Studies in animals have shown that U-50488 does not cause respiratory depression or constipation but it can cause diuresis and dysphoria . While U-50488 was developed as a non-addicting analgesic agent, it never received FDA-approval nor has it been. Furthermore, although equianalgesic doses of morphine and U‐50,488 reduced the number of labelled neurons in the spinal cord to a comparable extent, morphine reduced the number of immunoreactive neurons in the NTS to a greater extent than did U‐50,488. These results suggest that morphine and U‐50,488 have comparable effects on the transmission of visceral nociceptive messages by spinal.

Portal of the UNODC ICE Programme. Names: U-50488 3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamid U-50,488, (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamide hydrochloride)_, is a selective κ-opioid receptor agonist. In this study, we found that U-50,488 antagonized morphine-induced antinociception in morphine-naive guinea pigs at doses which did not have any antinociceptive effect by themselves (0.01-3 mg/kg). On the other hand, U-50,488 (3 mg/kg. Effects of the κ-opioid receptor agonist U-50,488 on morphine-induced place preference conditioning in the developing ra

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U-50488 je lek koji deluje kao visoko selektivni agonist κ-opioidnog receptora, bez μ-opioidnih antagonističkog dejstva. On ima analgetske, diuretske i antitusivne efekte, i poništava memorijski uticaj antiholinergičkih lekova. U-50488 je bio jedan od prvih selektivnih kapa agonista i istraživanja osobina njegovih derivata su dovela do razvoja velike familije srodnih jedinjenja Tip: The No More Sprite Tile Limits patch does NOT increase the limit for the amount of sprites onscreen at once. The SA-1 Pack does.: Not logged in Read Structure of κ‐agonist, U‐50488, Acta Crystallographica Section C: Structural Chemistry on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips U-50488 (n.). 1. A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE(From J Pharmacol Exp Ther 1997;280(1):416-21

DTC: (-)-U-50488 METHANE SULFONATE. Version: 02-September-2020 Alternate Names: CHEMBL1513237 ChEMBL Drug ID Drug Info: Publications: ChemblDrugs: chembl:CHEMBL1513237. Version: ChEMBL_27 Alternate Names: Drug Info: Publications: DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13. U-48800 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69593, which share very similar structures. Although not used medically, the selective kappa ligands are used in research (Research chemical, 2018). U-4990 (+/-)-trans-u-50488 67198-13-4 Suppliers,provide (+/-)-trans-u-50488 67198-13-4 product and the products related with China (Mainland) (+/-)-trans-u-50488 67198-13-4. 3.2.4 Konzentrationsabhängige Wirkung von U-50,488 auf die basale 28 cAMP-Bildung, bei Vorstimulation mit Isoprenalin (10 uM) oder Forskolin (10 uM) 3.3 Messung der Zeillängenänderung isolierter, elektrisch stimulierter 30 Kardiomyozyten: Einfluss des Phospholipase C-Inhibitors U-73,122 und des Proteinkinase C-Inhibitors Chelerythrin auf die Zelllängenänderung in Anwesenheit von. Addressing Hazards from Unscheduled Novel Psychoactive Substances as Research Chemicals: The Case of U-50488. Amin ZM, Rambaran KA, Fleming SW, Cho K, Chacko L, Alzghari SK

trans-U-50488 methanesulfonate salt CAS 83913-05-7

Structure, properties, spectra, suppliers and links for: (+)-U-50488 hydrochloride, 107902-84-1 Chemsrc provides (-)-u-50488 hydrochloride(CAS#:133162-85-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of (-)-u-50488 hydrochloride are included as well Product Name:(±)-U-50488 hydrochloride Catalog NO.:BCC6665. CAS NO.:67197-96- Molecular Formula:C 19 H 26 Cl 2 N 2 O.HCl Molecular Weight:405.79 Chemical Name:trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride Purify method:HPLC-DAD Purity:>98% as determined by HPLC storage:Desiccate at RT Solubility:Soluble to 25 mM in wate U-50488E CAS 67197-96- WIKI information includes physical and chemical properties, USES, security data, NMR spectroscopy, computational chemical data and more U-50488 caused hyperpolarization, and decreased input resistance and the action potential discharge in respiratory neurons. The effects of U-50488 were antagonized by nor-binaltorphimine. DAMGO (0.

(±)-trans-U-50488 methanesulfonate salt . INQUIRY Add to cart. For Research Use Only | Not For Clinical Use Specification Properties Related Products Product Q&A. CAT: IAR4245452: MDL Number: MFCD00133867: Molecular Weight: 465.43: InChI Key: OJPHNZCUXUUVKU-JAXOOIEVSA-N: Size: 10MG, 50MG, 100MG: Solubility: H2O: 50 mg/mL : Storage Conditions: 2-8°C: I-OMe-Tyrphostin AG 538; TFLLR-NH2. Home; About Us; Chromatography Products. CHROMATOGRAPHY COLUMNS. Chiral HPLC & SFC Columns; Achiral SFC Columns; Reversed-Phase HPLC Columns; Immobilized Artificia U-50488 (hydrochloride) U-50488 (hydrochloride) Supplier: Cayman Chemical Forensics. Catalogue number: CAY19363-5 mg. Size: 5 mg. Product is available in: POA. add to basket . Shipping is calculated in checkout . For price and ordering please contact us. Overview An analytical reference material categorized as an opioid; intended for research and forensic applications. Product Name:(-)-U-50488 hydrochloride Catalog NO.:BCC6666. CAS NO.:114528-79-9 Molecular Formula:C 19 H 26 Cl 2 N 2 O.HCl Molecular Weight:405.79 Chemical Name:trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride Purify method:HPLC-DAD Purity:>98% as determined by HPLC storage:Desiccate at RT Solubility:Soluble to 100 mM in water and to 100 mM in DMS U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures. Although not used medically, the selective kappa ligands are used in research. Buy U-47700 Online. Uses of U4770

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Buy (+/-)-U-50488 Hydrochloride [67197-96-0] (U850328) from Toronto Research Chemicals, online at bio-connect.n In diesem Forum können Geflügelhalter ihre Erfahrungen austauschen. Wenn dies Ihr erster Besuch hier ist, lesen Sie bitte zuerst die Hilfe - Häufig gestellte Fragen durch. Sie müssen sich registrieren, bevor Sie Beiträge verfassen können.Klicken Sie oben auf 'Registrieren', um den Registrierungsprozess zu starten

MULTYSTRIPE ist die Agentur für erfolgreiche Lösungen in den Bereichen Einlasskontrolle, Textilien für Marketing und Merchandising, sowie individuelle Werbemittel. Wir verbinden jahrelange Erfahrung und Marketing-Know-how mit einem ausgeprägten Sinn für Design und Trends Mir fällt auf,dass sich hauptsächlich Menschen die aus anderen Ländern kommen u. ausländisch aussehen,davon betroffen fühlen. Ich bin eine deutsche Frau ,bin 75 Jahre alt habe erwachsene Kinder bin verheiratet. In meinem Heimatort leben viele Menschen verschiedenster Kultur friedlich beieinander. In einer Fußgängerzohne wo Fahrradfahren untersagt ist, wurde ich von einem Schüler. 0155 181 50488 +49155 18150488 +49155 18 15 0488 +49155 181 50488 +49 155 18150488 +49 155 18 15 0488 +49 155 181 50488..... Diese Webseite analysiert das Nutzungsverhalten der Besucher, u.a. mithilfe von Cookies, zu Zwecken der Reichweitenmessung, der Optimierung des Angebots und der Personalisierung von Inhalten und Werbung. Unsere Partner für soziale Netzwerke, Werbung und Analysen führen. Mehr als 10 000 000 Spitznamen; Zufälliger Spitznamengenerator mit optionalen Fantasiesymbolen; Reputation und Ich bin, Ich weiß Buchhalter; Viele verschiedene Spitznamen für verschiedene Name Organisms Chromosomes Start Stop.

0176 360 50488 +49176 36050488 +49176 36 05 0488 +49176 360 50488 +49 176 36050488 +49 176 36 05 0488 +49 176 360 50488..... Diese Webseite analysiert das Nutzungsverhalten der Besucher, u.a. mithilfe von Cookies, zu Zwecken der Reichweitenmessung, der Optimierung des Angebots und der Personalisierung von Inhalten und Werbung. Unsere Partner für soziale Netzwerke, Werbung und Analysen führen. Boc Sciences offers (+)-U-50488 hydrochloride (114528-81-3) in bulk, please inquire us to get a quote for (+)-U-50488 hydrochloride (114528-81-3) Reibungsloser Prozessablauf und termingerechte Fahrzeugauslieferung durch präzise und schnelle Nacharbeit. Zeitersparnis durch Politur mit höherer Drehzahl (max. 2.000 U/min) Lieferumfang: 1 Stück Polierschwamm 3M 50488. 1 Stück Polierschwamm 3M 50487. 1 Stück Polierschwamm 3M 50388. Preis: 48,58 € boote-forum.de - Das Forum rund um Boote https://www.boote-forum.d Zeitersparnis durch Politur mit höherer Drehzahl (max. 2.000 U/min) Inhalt: 1 Stück x 50488, 1 Stück x 50487, 1 Stück x 50388 Preis: 47,55 € für 3M Perfect-IT III Polierschwamme SET (1 Stück x 50488, 1 Stück x 50487, 1 Stück x 50388 ) Bezahlung: Wir akzeptieren folgende Zahlungsmethodem: Banküberweisung un

U e 24V I e 1A Kurzschlusssicherung nach IEC 60269-11) 2 A gG Masse ca. 1,1 kg ≥ 145 W / km Leiterquerschnitt 0,14 mm2 Leitungslänge 5 m Bemessungsstoßspannungs-festigkeit U imp = 1,5 kV Bemessungsisolations-spannung U i = 250 V Bedingter Kurzschlussstrom 100 A Zuverlässigkeitswerte nach EN ISO 13849-1 B 10d 1 x 105 1) Bei abweichenden Leitungslängen muss die Kurzschlusssicherung. Nummer der Genehmigung: 50488 Erweiterung Nr.: 01 Approval No. Extension No.: 14. 15. 16. Ort: Place: Datum: Date: Unterschrift: Signature: DE-24932 Flensburg 08.09.2017 Im Auftrag 17. Beigefügt ist eine Liste der Genehmigungsunterlagen, die bei der zuständigen Genehmigungsbehörde hinterlegt sind und von denen eine Kopie auf Anfrage erhältlich ist. Annexed is a list of documents making up. Buy high quality (-)-U-50488 hydrochloride from Musechem. Please inquire us to get a quote for cas 114528-79-9,(-)-U-50488 hydrochloride

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  3. U-series drug deaths include those involving U-47700 and its analogs U-48800 and U-49900. U-47700, a nonfentanyl benzamide compound developed by a pharmaceutical company, is not authorized for medical use in the United States and is currently distributed illicitly for its heroin-like effect. Deaths involving U-50488 and U-51754 were also included in this category, but each was involved in five.
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